InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Smad6

Summary

InnateDB Gene

IDBG-175757.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smad6

Gene Name

SMAD family member 6

Synonyms

b2b390Clo; Madh6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036867

Encoded Proteins

IDBP-175759

MAD homolog 6 (Drosophila)

IDBP-741919

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 16951688

[Homo sapiens] SMAD6 is a critical mediator of the TGF-beta-BMP pathway that mediates anti-inflammatory activity and negatively regulates IL-1R-Toll-like receptor signals.

PMID 20171181

[Homo sapiens] SMAD6 acts a critical mediator for effective TGF-beta1-mediated suppression of IL-1R/TLR signalling, by simultaneous binding to discrete regions of Pellino-1.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137834:
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila \'mothers against decapentaplegic\' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:63953076-64022059

Strand

Reverse strand

Band

Transcripts

ENSMUST00000041029	ENSMUSP00000036285
ENSMUST00000144323
ENSMUST00000179458	ENSMUSP00000137442

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0031625	ubiquitin protein ligase binding
GO:0034713	type I transforming growth factor beta receptor binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding
GO:0070410	co-SMAD binding
GO:0070411	I-SMAD binding
GO:0070412	R-SMAD binding
GO:0070698	type I activin receptor binding

Biological Process

GO:0001657	ureteric bud development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006955	immune response
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007352	zygotic specification of dorsal/ventral axis
GO:0008285	negative regulation of cell proliferation
GO:0010991	negative regulation of SMAD protein complex assembly
GO:0030509	BMP signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0031589	cell-substrate adhesion
GO:0034616	response to laminar fluid shear stress
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0043627	response to estrogen
GO:0045444	fat cell differentiation
GO:0045907	positive regulation of vasoconstriction
GO:0045908	negative regulation of vasodilation
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060948	cardiac vascular smooth muscle cell development
GO:0060977	coronary vasculature morphogenesis