Mus musculus Gene: Rbm8a
Summary
InnateDB Gene IDBG-175839.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rbm8a
Gene Name RNA binding motif protein 8a
Synonyms 2310057C03Rik; AA673428; Rbm8
Species Mus musculus
Ensembl Gene ENSMUSG00000038374
Encoded Proteins
RNA binding motif protein 8a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:96629928-96633779
Strand Forward strand
Band F2.1
Transcripts
ENSMUST00000048915 ENSMUSP00000044548
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 69 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0006417 regulation of translation
GO:0008380 RNA splicing
GO:0051028 mRNA transport
Cellular Component
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
mRNA 3'-end processing pathway
Transport of Mature Transcript to Cytoplasm pathway
mRNA Splicing pathway
Nonsense-Mediated Decay (NMD) pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
RNA Polymerase II Transcription Termination pathway
Cleavage of Growing Transcript in the Termination Region pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
RNA Polymerase II Transcription pathway
KEGG
Spliceosome pathway
RNA transport pathway
mRNA surveillance pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
mRNA 3'-end processing pathway
mRNA Splicing - Major Pathway pathway
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
Cleavage of Growing Transcript in the Termination Region pathway
Nonsense-Mediated Decay (NMD) pathway
RNA Polymerase II Transcription Termination pathway
RNA Polymerase II Transcription pathway
Transport of Mature Transcript to Cytoplasm pathway
mRNA Splicing pathway
Gene Expression pathway
RNA Polymerase II Transcription pathway
Cleavage of Growing Transcript in the Termination Region pathway
mRNA Splicing - Major Pathway pathway
mRNA Splicing pathway
mRNA 3'-end processing pathway
Transport of Mature Transcript to Cytoplasm pathway
RNA Polymerase II Transcription Termination pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Gene Expression pathway
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
Nonsense-Mediated Decay (NMD) pathway
KEGG
Spliceosome pathway
RNA transport pathway
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.261972 Mm.398764
RefSeq NM_001102407 NM_025875
OMIM
CCDS CCDS51005
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas