Version 5.4
Mus musculus Gene: Amh
Summary
InnateDB Gene IDBG-176152.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Amh
Gene Name anti-Mullerian hormone
Synonyms MIS
Species Mus musculus
Ensembl Gene ENSMUSG00000035262
Encoded Proteins
IDBP-176154
anti-Mullerian hormone
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the transforming growth factor-beta superfamily of growth and differentiation factors. The encoded protein is produced in fetal Sertoli cells during male gonadal differentiation. The protein binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in developing male embryos. In humans, some mutations in this gene are associated with persistent Mullerian duct syndrome (PMDS). [provided by RefSeq, Apr 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:80805248-80807648
Strand Forward strand
Band C1
Transcripts
ENSMUST00000036016 ENSMUSP00000043153
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005160 transforming growth factor beta receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001541 ovarian follicle development
GO:0001546 preantral ovarian follicle growth
GO:0001655 urogenital system development
GO:0001880 Mullerian duct regression
GO:0007568 aging
GO:0008406 gonad development
GO:0010628 positive regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0042493 response to drug
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104899
View Gene Order
ENSBTAG00000014955
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04350
TGF-beta signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04350
TGF-beta signaling pathway pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
alk2pathway
ALK2 signaling events
Cross-References
SwissProt
TrEMBL Q5EC55
UniProt Splice Variant
Entrez Gene 11705
UniGene Mm.376094
RefSeq NM_007445
OMIM
CCDS CCDS24033
HPRD
IMGT
MGI ID MGI:88006
MGI Symbol Amh
EMBL AC166937 AY911505 CH466553
GenPept AAW84293 EDL31495
RNA Seq Atlas 11705

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca