Mus musculus Gene: Dusp5 | |||||||||||||
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Summary | |||||||||||||
InnateDB Gene | IDBG-176683.6 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | Dusp5 | ||||||||||||
Gene Name | dual specificity phosphatase 5 | ||||||||||||
Synonyms | |||||||||||||
Species | Mus musculus | ||||||||||||
Ensembl Gene | ENSMUSG00000034765 | ||||||||||||
Encoded Proteins |
dual specificity phosphatase 5
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Protein Structure | |||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
Entrez Gene | |||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138166:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008] The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||
Type | Protein coding | ||||||||||||
Genomic Location | Chromosome 19:53529109-53542431 | ||||||||||||
Strand | Forward strand | ||||||||||||
Band | D2 | ||||||||||||
Transcripts |
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Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||
NETPATH | |||||||||||||
REACTOME | |||||||||||||
KEGG |
MAPK signaling pathway pathway
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INOH | |||||||||||||
PID NCI | |||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||
NETPATH | |||||||||||||
REACTOME | |||||||||||||
KEGG |
MAPK signaling pathway pathway
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INOH | |||||||||||||
PID NCI |
Direct p53 effectors
ATF-2 transcription factor network
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Cross-References | |||||||||||||
SwissProt | |||||||||||||
TrEMBL | Q1HL35 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 240672 | ||||||||||||
UniGene | Mm.409998 Mm.482424 Mm.52043 | ||||||||||||
RefSeq | NM_001085390 | ||||||||||||
OMIM | |||||||||||||
CCDS | CCDS38024 | ||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
MGI ID | MGI:2685183 | ||||||||||||
MGI Symbol | Dusp5 | ||||||||||||
EMBL | AC137853 CH466585 DQ479917 | ||||||||||||
GenPept | ABF48498 EDL01705 | ||||||||||||
RNA Seq Atlas | 240672 | ||||||||||||