Mus musculus Gene: Pak3 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Gene | IDBG-176809.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | Pak3 | ||||||||||||||||||||||||||||
Gene Name | p21 protein (Cdc42/Rac)-activated kinase 3 | ||||||||||||||||||||||||||||
Synonyms | PAK-3; Pak65alpha; Pak65beta; Stk4 | ||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000031284 | ||||||||||||||||||||||||||||
Encoded Proteins |
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
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Protein Structure | |||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077264:
PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||
Genomic Location | Chromosome X:143518591-143797796 | ||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||
Band | F2 | ||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||
REACTOME |
Signaling by VEGF pathway
Sema3A PAK dependent Axon repulsion pathway
Immune System pathway
Signaling by Robo receptor pathway
EPH-Ephrin signaling pathway
CD28 dependent Vav1 pathway pathway
CD28 co-stimulation pathway
Costimulation by the CD28 family pathway
VEGFR2 mediated vascular permeability pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Adaptive Immune System pathway
Developmental Biology pathway
Ephrin signaling pathway
Semaphorin interactions pathway
Signal Transduction pathway
Generation of second messenger molecules pathway
Activation of Rac pathway
TCR signaling pathway
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KEGG |
Axon guidance pathway
Renal cell carcinoma pathway
ErbB signaling pathway pathway
T cell receptor signaling pathway pathway
Regulation of actin cytoskeleton pathway
Focal adhesion pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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PID NCI | |||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||
REACTOME |
Generation of second messenger molecules pathway
CD28 dependent Vav1 pathway pathway
CD28 co-stimulation pathway
Costimulation by the CD28 family pathway
Sema3A PAK dependent Axon repulsion pathway
Activation of Rac pathway
Signaling by Robo receptor pathway
Developmental Biology pathway
TCR signaling pathway
Semaphorin interactions pathway
Signaling by VEGF pathway
Innate Immune System pathway
VEGFR2 mediated vascular permeability pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
Ephrin signaling pathway
VEGFA-VEGFR2 Pathway pathway
EPH-Ephrin signaling pathway
FCERI mediated MAPK activation pathway
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KEGG |
Regulation of actin cytoskeleton pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
Axon guidance pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
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INOH | |||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||
TrEMBL | A3KGC2 A3KGC3 | ||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | 18481 | ||||||||||||||||||||||||||||
UniGene | Mm.40035 Mm.474844 | ||||||||||||||||||||||||||||
RefSeq | NM_001195046 NM_001195047 NM_001195048 NM_001195049 NM_008778 XM_006528747 XM_006528748 XM_006528749 XM_006528750 XM_006528751 XM_006528752 XM_006528753 XM_006528754 | ||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||
CCDS | CCDS30454 CCDS57779 | ||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
MGI ID | MGI:1339656 | ||||||||||||||||||||||||||||
MGI Symbol | Pak3 | ||||||||||||||||||||||||||||
EMBL | AL691499 BX322533 BX530055 BX813331 | ||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||
RNA Seq Atlas | 18481 | ||||||||||||||||||||||||||||