InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adra2a

Summary

InnateDB Gene

IDBG-177063.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adra2a

Gene Name

adrenergic receptor, alpha 2a

Synonyms

Adra-2; Adra-2a; alpha(2A)AR; alpha2-C10; alpha2A; alpha2A-AR; AW122659

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033717

Encoded Proteins

IDBP-177065

adrenergic receptor, alpha 2a

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150594:
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:54045182-54048982

Strand

Forward strand

Band

Transcripts

ENSMUST00000036700

ENSMUSP00000036203

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004935	adrenergic receptor activity
GO:0004938	alpha2-adrenergic receptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0031696	alpha-2C adrenergic receptor binding
GO:0031996	thioesterase binding
GO:0032795	heterotrimeric G-protein binding
GO:0042803	protein homodimerization activity
GO:0051379	epinephrine binding
GO:0051380	norepinephrine binding

Biological Process

GO:0001819	positive regulation of cytokine production
GO:0002526	acute inflammatory response
GO:0006260	DNA replication
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007565	female pregnancy
GO:0019229	regulation of vasoconstriction
GO:0030168	platelet activation
GO:0030335	positive regulation of cell migration
GO:0032147	activation of protein kinase activity
GO:0032148	activation of protein kinase B activity
GO:0032870	cellular response to hormone stimulus
GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0042593	glucose homeostasis
GO:0042596	fear response
GO:0043406	positive regulation of MAP kinase activity
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
GO:0045909	positive regulation of vasodilation
GO:0045955	negative regulation of calcium ion-dependent exocytosis
GO:0046676	negative regulation of insulin secretion
GO:0050955	thermoception
GO:0050995	negative regulation of lipid catabolic process
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070473	negative regulation of uterine smooth muscle contraction
GO:0071881	adenylate cyclase-inhibiting adrenergic receptor signaling pathway
GO:0071882	phospholipase C-activating adrenergic receptor signaling pathway
GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway
GO:0090303	positive regulation of wound healing

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex
GO:0045202	synapse