Version 5.4
Mus musculus Gene: Orc6
Summary
InnateDB Gene IDBG-177097.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Orc6
Gene Name origin recognition complex, subunit 6
Synonyms 6720420I10Rik; Orc6l
Species Mus musculus
Ensembl Gene ENSMUSG00000031697
Encoded Proteins
IDBP-177099
origin recognition complex, subunit 6
IDBP-621215
origin recognition complex, subunit 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091651:
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:85299632-85308278
Strand Forward strand
Band C3
Transcripts
ENSMUST00000034132 ENSMUSP00000034132
ENSMUST00000170141 ENSMUSP00000126925
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
Cellular Component
GO:0000808 origin recognition complex
GO:0005664 nuclear origin of replication recognition complex
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000091651
View Gene Order
ENSBTAG00000001872
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04110
Cell cycle pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_1707
CDC6 association with the ORC:origin complex pathway
REACT_1949
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_567
Assembly of the ORC complex at the origin of replication pathway
REACT_2243
Assembly of the pre-replicative complex pathway
REACT_1321
E2F-enabled inhibition of pre-replication complex formation pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_828
G2/M Checkpoints pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_829
Regulation of DNA replication pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_222889
E2F-enabled inhibition of pre-replication complex formation pathway
REACT_225014
S Phase pathway
REACT_206368
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_224358
Mitotic G1-G1/S phases pathway
REACT_207739
DNA Replication Pre-Initiation pathway
REACT_213604
DNA Replication pathway
REACT_215677
Assembly of the pre-replicative complex pathway
REACT_211609
G1/S Transition pathway
REACT_212671
Regulation of DNA replication pathway
REACT_213030
Orc1 removal from chromatin pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_201998
E2F mediated regulation of DNA replication pathway
REACT_224922
Synthesis of DNA pathway
REACT_214934
Cell Cycle pathway
REACT_208424
Assembly of the ORC complex at the origin of replication pathway
REACT_223713
CDC6 association with the ORC:origin complex pathway
REACT_226955
M/G1 Transition pathway
REACT_206537
G2/M Checkpoints pathway
REACT_221628
Activation of the pre-replicative complex pathway
REACT_227740
Activation of ATR in response to replication stress pathway
REACT_205537
Removal of licensing factors from origins pathway
REACT_224819
Cell Cycle Checkpoints pathway
REACT_222483
Switching of origins to a post-replicative state pathway
KEGG
hsa04110
Cell cycle pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q3TQX1
UniProt Splice Variant
Entrez Gene 56452
UniGene Mm.29709 Mm.398482
RefSeq NM_001163791 NM_019716
OMIM
CCDS CCDS52623 CCDS22497
HPRD
IMGT
MGI ID MGI:1929285
MGI Symbol Orc6
EMBL AC134854 AK163256
GenPept BAE37261
RNA Seq Atlas 56452

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca