Version 5.4
| Mus musculus Gene: Irak4 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-177236.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Irak4 | ||||||||||||||||||||||
| Gene Name | interleukin-1 receptor-associated kinase 4 | ||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000059883 | ||||||||||||||||||||||
| Encoded Proteins |
interleukin-1 receptor-associated kinase 4
interleukin-1 receptor-associated kinase 4
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||
| Summary |
IRAK4-mediated innate immune inflammatory responses play critical roles in divergent clinical outcomes in murine malaria models when Irak4 (-/-) mice were used to study two experimental models of malaria.
Irak4 activation is impaired during endotoxin tolerization; a process which impairs the production of LPS-induced pro-inflammatory cytokines without inhibition expression of anti-inflammatory or anti-microbial mediators.
Irak4 deficient mice show impaired innate immunity, leading to defective Type 1 T-cell responses, B-cell expansion, and are more susceptible to Toxoplasma gondii infection.
Mir302b expression is up-regulated upon bacterial infection and is a crucial regulator of NFκB signalling by directly targeting IRAK4
Irak4 is a molecular target of chlorogenic acid in the treatment of innate immunity-related shock and organ dysfunction following insult of various Toll-like receptor pathogens from bacteria and viruses.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Homo sapiens] IRAK4 is required for interleukin-1 receptor/toll-like receptor-induced MAP3K7 (TAK1)-dependent NF-kappaB activation.
[Homo sapiens] IRAK4 and IRAK1 play key roles in a signalling pathway by which bacterial infection or IL-1 trigger the production of inflammatory mediators.
[Homo sapiens] IRAK4 is indispensable for the responses of animals and cultured cells to IL-1 and ligands that stimulate various Toll-like receptors (TLRs).
[Homo sapiens] IRAK4 plays a critical role in IL-1R and TLR signalling cascades and is an essential component of the IL-18 signalling cascade.
[Homo sapiens] IRAK4 activation is impaired during endotoxin tolerization; a process which impairs the production of LPS-induced pro-inflammatory cytokines without inhibition expression of anti-inflammatory or anti-microbial mediators.
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198001:
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 15:94543643-94581815 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | E3 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
MyD88 cascade initiated on plasma membrane pathway
Cytokine Signaling in Immune system pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll-Like Receptors Cascades pathway
Signaling by Interleukins pathway
MyD88 dependent cascade initiated on endosome pathway
Activated TLR4 signalling pathway
Interleukin-1 signaling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
Toll-like receptor signaling pathway pathway
Apoptosis pathway
Neurotrophin signaling pathway pathway
Leishmaniasis pathway
Toxoplasmosis pathway
Chagas disease (American trypanosomiasis) pathway
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| INOH |
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
IL1 pathway
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| REACTOME |
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Interleukin-1 signaling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
Signaling by Interleukins pathway
Activated TLR4 signalling pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Activated TLR4 signalling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Toll-Like Receptors Cascades pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MyD88 dependent cascade initiated on endosome pathway
Innate Immune System pathway
Interleukin-1 signaling pathway
Signaling by Interleukins pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
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| KEGG |
Apoptosis pathway
Toll-like receptor signaling pathway pathway
Neurotrophin signaling pathway pathway
Leishmaniasis pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
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| INOH |
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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| PID NCI |
IL1-mediated signaling events
Endogenous TLR signaling
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| Cross-References | |||||||||||||||||||||||
| SwissProt | Q8R4K2 | ||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 266632 | ||||||||||||||||||||||
| UniGene | Mm.422858 | ||||||||||||||||||||||
| RefSeq | NM_029926 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS27772 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | MGI:2182474 | ||||||||||||||||||||||
| MGI Symbol | Irak4 | ||||||||||||||||||||||
| EMBL | AF445803 AK028837 BC051676 | ||||||||||||||||||||||
| GenPept | AAH51676 AAM15773 BAC26146 | ||||||||||||||||||||||
| RNA Seq Atlas | 266632 | ||||||||||||||||||||||