InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hist3h2ba

Summary

InnateDB Gene

IDBG-177590.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hist3h2ba

Gene Name

histone cluster 3, H2ba

Synonyms

1500011O09Rik; AI413321

Species

Mus musculus

Ensembl Gene

ENSMUSG00000056895

Encoded Proteins

histone cluster 3, H2ba

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. [provided by RefSeq, Mar 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:58948920-58949533

Strand

Forward strand

Band

B1.3

Transcripts

ENSMUST00000078267

ENSMUSP00000076397

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006334	nucleosome assembly
GO:0008150	biological_process

Cellular Component

GO:0000786	nucleosome
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000196890

View Gene Order

Pathways

NETPATH

REACTOME

Meiotic Recombination pathway

Meiotic Synapsis pathway

Mus musculus biological processes pathway

NoRC negatively regulates rRNA expression pathway

Chromatin organization pathway

HATs acetylate histones pathway

Meiotic synapsis pathway

Cell Cycle pathway

NoRC negatively regulates rRNA expression pathway

Chromatin modifying enzymes pathway

Epigenetic regulation of gene expression pathway

Gene Expression pathway

DNA methylation pathway

Negative epigenetic regulation of rRNA expression pathway

Meiosis pathway

KEGG

mmu05322

Systemic lupus erythematosus pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

Systemic lupus erythematosus pathway

INOH

PID NCI

Cross-References

SwissProt

Q9D2U9

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_030082

OMIM

CCDS

CCDS24754

HPRD

IMGT

MGI ID

MGI:1925553

MGI Symbol

Hist3h2ba

EMBL

AK018765 AY158942 BC051921

GenPept

AAH51921 AAO06252 BAB31395

RNA Seq Atlas

382522 78303

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca