InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rcan1

Summary

InnateDB Gene

IDBG-177629.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rcan1

Gene Name

regulator of calcineurin 1

Synonyms

Adapt78; CALP1L; CSP1; DSC1; Dscr1; MCIP1; RCN1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022951

Encoded Proteins

IDBP-177631

regulator of calcineurin 1

IDBP-177633

regulator of calcineurin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19716405

[Homo sapiens] RCAN1 (DSCR1) short isoform positively modulates IL-1R-mediated signalling pathways by regulating TOLLIP/IRAK1/TRAF6 complex formation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159200:
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:92391953-92466146

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023672	ENSMUSP00000023672
ENSMUST00000060005	ENSMUSP00000060394

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002931	response to ischemia
GO:0006979	response to oxidative stress
GO:0007519	skeletal muscle tissue development
GO:0007614	short-term memory
GO:0009612	response to mechanical stimulus
GO:0019722	calcium-mediated signaling
GO:0031987	locomotion involved in locomotory behavior
GO:0033173	calcineurin-NFAT signaling cascade
GO:0043627	response to estrogen
GO:0043666	regulation of phosphoprotein phosphatase activity
GO:0048741	skeletal muscle fiber development
GO:0051151	negative regulation of smooth muscle cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000159200

View Gene Order

ENSBTAG00000020035

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

tcrcalciumpathway

Calcium signaling in the CD4+ TCR pathway

hes_heypathway

Notch-mediated HES/HEY network

nfat_3pathway

Role of Calcineurin-dependent NFAT signaling in lymphocytes

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.265744 Mm.455990

RefSeq

NM_001081549 NM_019466

OMIM

CCDS

CCDS28337 CCDS37405

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas