InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp2b2

Summary

InnateDB Gene

IDBG-178513.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp2b2

Gene Name

ATPase, Ca++ transporting, plasma membrane 2

Synonyms

D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy; wms; wri

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030302

Encoded Proteins

IDBP-178515

ATPase, Ca++ transporting, plasma membrane 2

IDBP-178519

ATPase, Ca++ transporting, plasma membrane 2

IDBP-178521

ATPase, Ca++ transporting, plasma membrane 2

IDBP-788597

ATPase, Ca++ transporting, plasma membrane 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157087:
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:113745669-114042613

Strand

Reverse strand

Band

Transcripts

ENSMUST00000089003	ENSMUSP00000086398
ENSMUST00000101045	ENSMUSP00000098606
ENSMUST00000101044	ENSMUSP00000098605
ENSMUST00000152831	ENSMUSP00000138165
ENSMUST00000135199
ENSMUST00000144507
ENSMUST00000154738

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0019829	cation-transporting ATPase activity
GO:0030165	PDZ domain binding
GO:0030899	calcium-dependent ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006200	ATP catabolic process
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006996	organelle organization
GO:0007595	lactation
GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0008361	regulation of cell size
GO:0021549	cerebellum development
GO:0021692	cerebellar Purkinje cell layer morphogenesis
GO:0021702	cerebellar Purkinje cell differentiation
GO:0021707	cerebellar granule cell differentiation
GO:0030182	neuron differentiation
GO:0040011	locomotion
GO:0042428	serotonin metabolic process
GO:0042472	inner ear morphogenesis
GO:0045299	otolith mineralization
GO:0046068	cGMP metabolic process
GO:0048167	regulation of synaptic plasticity
GO:0048839	inner ear development
GO:0050808	synapse organization
GO:0050885	neuromuscular process controlling balance
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
GO:0051480	cytosolic calcium ion homeostasis
GO:0051928	positive regulation of calcium ion transport
GO:0060088	auditory receptor cell stereocilium organization
GO:0060113	inner ear receptor cell differentiation
GO:0070588	calcium ion transmembrane transport
GO:0090102	cochlea development

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0043025	neuronal cell body