Version 5.4
Mus musculus Gene: Pigp
Summary
InnateDB Gene IDBG-178575.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pigp
Gene Name phosphatidylinositol glycan anchor biosynthesis, class P
Synonyms Dcrc; Dscr5
Species Mus musculus
Ensembl Gene ENSMUSG00000022940
Encoded Proteins
IDBP-252870
phosphatidylinositol glycan anchor biosynthesis, class P
IDBP-252872
phosphatidylinositol glycan anchor biosynthesis, class P
IDBP-252874
phosphatidylinositol glycan anchor biosynthesis, class P
IDBP-252876
phosphatidylinositol glycan anchor biosynthesis, class P
IDBP-252878
phosphatidylinositol glycan anchor biosynthesis, class P
IDBP-541457
phosphatidylinositol glycan anchor biosynthesis, class P
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185808:
This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:94358763-94371015
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000113917 ENSMUSP00000109550
ENSMUST00000113914 ENSMUSP00000109547
ENSMUST00000113910 ENSMUSP00000109543
ENSMUST00000113906 ENSMUSP00000109539
ENSMUST00000113905 ENSMUSP00000109538
ENSMUST00000146924
ENSMUST00000138514 ENSMUSP00000114477
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity
Biological Process
GO:0006506 GPI anchor biosynthetic process
Cellular Component
GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000185808
View Gene Order
Pathways
NETPATH
REACTOME
REACT_244576
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_243945
Synthesis of glycosylphosphatidylinositol (GPI) pathway
KEGG
mmu00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_952
Synthesis of glycosylphosphatidylinositol (GPI) pathway
REACT_1853
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001159616 NM_001159617 NM_001159618 NM_001159619 NM_001159620 NM_019543
OMIM
CCDS CCDS28348 CCDS49918 CCDS49919 CCDS49920
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca