InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: S1pr4

Summary

InnateDB Gene

IDBG-178731.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S1pr4

Gene Name

sphingosine-1-phosphate receptor 4

Synonyms

Edg6; Lpc1; S1p4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000044199

Encoded Proteins

IDBP-178733

sphingosine-1-phosphate receptor 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The encoded protein is one of the predominant sphingosine 1-phosphate G-protein coupled receptors expressed in T cells, and it plays a role in suppression of T cell proliferation, generation of cytokines, and potentially other aspects of immune activation. [provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:81497745-81500132

Strand

Reverse strand

Band

Transcripts

ENSMUST00000053646

ENSMUSP00000050412

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0038036	sphingosine-1-phosphate receptor activity

Biological Process

GO:0003376	sphingosine-1-phosphate signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway