InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc6a1

Summary

InnateDB Gene

IDBG-178837.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc6a1

Gene Name

solute carrier family 6 (neurotransmitter transporter, GABA), member 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030310

Encoded Proteins

IDBP-178839

solute carrier family 6 (neurotransmitter transporter, GABA), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157103:
The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:114282635-114317522

Strand

Forward strand

Band

Transcripts

ENSMUST00000032454

ENSMUSP00000032454

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005328	neurotransmitter:sodium symporter activity
GO:0005332	gamma-aminobutyric acid:sodium symporter activity
GO:0005515	protein binding

Biological Process

GO:0006836	neurotransmitter transport
GO:0007612	learning
GO:0009636	response to toxic substance
GO:0009744	response to sucrose stimulus
GO:0010033	response to organic substance
GO:0010243	response to organonitrogen compound
GO:0010288	response to lead ion
GO:0014054	positive regulation of gamma-aminobutyric acid secretion
GO:0014070	response to organic cyclic compound
GO:0014074	response to purine-containing compound
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0032355	response to estradiol
GO:0042220	response to cocaine
GO:0051260	protein homooligomerization
GO:0051592	response to calcium ion
GO:0051939	gamma-aminobutyric acid import
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043005	neuron projection