Version 5.4
Mus musculus Gene: Kcnj6
Summary
InnateDB Gene IDBG-179137.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnj6
Gene Name potassium inwardly-rectifying channel, subfamily J, member 6
Synonyms BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver; wv
Species Mus musculus
Ensembl Gene ENSMUSG00000043301
Encoded Proteins
IDBP-179141
potassium inwardly-rectifying channel, subfamily J, member 6
IDBP-179143
potassium inwardly-rectifying channel, subfamily J, member 6
IDBP-626288
potassium inwardly-rectifying channel, subfamily J, member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157542:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:94749266-94997696
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000095873 ENSMUSP00000093558
ENSMUST00000099508 ENSMUSP00000097108
ENSMUST00000165538 ENSMUSP00000130321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005242 inward rectifier potassium channel activity
GO:0005515 protein binding
GO:0015467 G-protein activated inward rectifier potassium channel activity
Biological Process
GO:0006813 potassium ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000157542
View Gene Order
ENSBTAG00000037616
Not yet available
Pathways
NETPATH
REACTOME
REACT_214393
Inwardly rectifying K+ channels pathway
REACT_208267
G protein gated Potassium channels pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_207065
Activation of GABAB receptors pathway
REACT_202800
Potassium Channels pathway
REACT_217868
GABA B receptor activation pathway
REACT_224131
GABA receptor activation pathway
REACT_259290
Neuronal System pathway
REACT_226457
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_208837
Activation of G protein gated Potassium channels pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25004
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
REACT_25031
GABA B receptor activation pathway
REACT_75831
Activation of G protein gated Potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_25199
GABA receptor activation pathway
REACT_75780
G protein gated Potassium channels pathway
REACT_25330
Activation of GABAB receptors pathway
REACT_75918
Inwardly rectifying K+ channels pathway
REACT_75908
Potassium Channels pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.328720
RefSeq NM_001025584 NM_001025590 NM_010606 XM_006522953
OMIM
CCDS CCDS37408 CCDS37409 CCDS49921
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca