InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cd2

Summary

InnateDB Gene

IDBG-179684.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd2

Gene Name

CD2 antigen

Synonyms

LFA-2; Ly-37; Ly37

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027863

Encoded Proteins

IDBP-179686

CD2 antigen

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116824:
CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]
CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95%% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:101275899-101287939

Strand

Reverse strand

Band

F2.2

Transcripts

ENSMUST00000029456	ENSMUSP00000029456
ENSMUST00000156103
ENSMUST00000152321

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0007155	cell adhesion
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034113	heterotypic cell-cell adhesion
GO:1902715	positive regulation of interferon-gamma secretion
GO:2000484	positive regulation of interleukin-8 secretion

Cellular Component

GO:0005576	extracellular region
GO:0005911	cell-cell junction
GO:0009897	external side of plasma membrane
GO:0009898	cytoplasmic side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0046658	anchored component of plasma membrane

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000116824

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

mmu04514

Cell adhesion molecules (CAMs) pathway

mmu04640

Hematopoietic cell lineage pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_11

TCR pathway

REACTOME

REACT_12051

Cell surface interactions at the vascular wall pathway

REACT_604

Hemostasis pathway

KEGG

hsa04640

Hematopoietic cell lineage pathway

hsa04514

Cell adhesion molecules (CAMs) pathway

INOH

PID NCI

Cross-References

SwissProt

P08920

TrEMBL

D3Z1E1 Q549Q4

UniProt Splice Variant

Entrez Gene

12481

UniGene

Mm.22842 Mm.468528

RefSeq

NM_013486

OMIM

CCDS

CCDS17681

HPRD

IMGT

MGI ID

MGI:88320

MGI Symbol

Cd2

EMBL

AC131184 AF065906 AF065907 AF065908 AL645930 BC053731 CH466608 M18934 M19799 M19801 M19803 M19805 M19807 X06143 Y00023

GenPept

AAA37393 AAA37397 AAD25886 AAD25887 AAD25888 AAH53731 CAA29500 CAA68258 EDL07629

RNA Seq Atlas

12481