InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp1a1

Summary

InnateDB Gene

IDBG-179812.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp1a1

Gene Name

ATPase, Na+/K+ transporting, alpha 1 polypeptide

Synonyms

Atpa-1; BC010319

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033161

Encoded Proteins

IDBP-179814

ATPase, Na+/K+ transporting, alpha 1 polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163399:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:101576219-101604603

Strand

Reverse strand

Band

F2.2

Transcripts

ENSMUST00000036493	ENSMUSP00000039657
ENSMUST00000130649
ENSMUST00000136340

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016791	phosphatase activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0030506	ankyrin binding
GO:0030955	potassium ion binding
GO:0031402	sodium ion binding
GO:0043531	ADP binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0046872	metal ion binding
GO:0051087	chaperone binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0002028	regulation of sodium ion transport
GO:0006754	ATP biosynthetic process
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0008217	regulation of blood pressure
GO:0010107	potassium ion import
GO:0015672	monovalent inorganic cation transport
GO:0016311	dephosphorylation
GO:0031947	negative regulation of glucocorticoid biosynthetic process
GO:0035725	sodium ion transmembrane transport
GO:0042493	response to drug
GO:0045822	negative regulation of heart contraction
GO:0045823	positive regulation of heart contraction
GO:0045989	positive regulation of striated muscle contraction
GO:0060081	membrane hyperpolarization
GO:0071260	cellular response to mechanical stimulus
GO:0086004	regulation of cardiac muscle cell contraction

Cellular Component

GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005890	sodium:potassium-exchanging ATPase complex
GO:0005901	caveola
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030315	T-tubule
GO:0042383	sarcolemma
GO:0042470	melanosome
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome