Version 5.4
Mus musculus Gene: Iqsec2
Summary
InnateDB Gene IDBG-180098.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Iqsec2
Gene Name IQ motif and Sec7 domain 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000041115
Encoded Proteins
IDBP-180100
IQ motif and Sec7 domain 2
IDBP-255661
IQ motif and Sec7 domain 2
IDBP-255663
IQ motif and Sec7 domain 2
IDBP-625820
IQ motif and Sec7 domain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124313:
This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:152144268-152225236
Strand Forward strand
Band F3
Transcripts
ENSMUST00000096275 ENSMUSP00000093995
ENSMUST00000112605 ENSMUSP00000108224
ENSMUST00000112604 ENSMUSP00000108223
ENSMUST00000146835
ENSMUST00000128724
ENSMUST00000153356
ENSMUST00000168786 ENSMUSP00000127249
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0030036 actin cytoskeleton organization
GO:0032012 regulation of ARF protein signal transduction
GO:0043087 regulation of GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0030054 cell junction
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000124313
View Gene Order
ENSBTAG00000014945
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A4GZ26 D3Z5I6 D3Z6V7 E9QAD8
UniProt Splice Variant
Entrez Gene 245666
UniGene Mm.33027 Mm.395684
RefSeq NM_001005475 NM_001114664 XM_006528844
OMIM
CCDS CCDS41177 CCDS53224
HPRD
IMGT
MGI ID MGI:3528396
MGI Symbol Iqsec2
EMBL AB275281 AC083816
GenPept BAF49453
RNA Seq Atlas 245666

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca