Version 5.4
Mus musculus Gene: Ap2a1
Summary
InnateDB Gene IDBG-180315.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ap2a1
Gene Name adaptor protein complex AP-2, alpha 1 subunit
Synonyms Adtaa
Species Mus musculus
Ensembl Gene ENSMUSG00000060279
Encoded Proteins
IDBP-180317
adaptor protein complex AP-2, alpha 1 subunit
IDBP-265768
adaptor protein complex AP-2, alpha 1 subunit
IDBP-628093
adaptor protein complex AP-2, alpha 1 subunit
IDBP-628094
adaptor protein complex AP-2, alpha 1 subunit
IDBP-628095
adaptor protein complex AP-2, alpha 1 subunit
IDBP-628097
adaptor protein complex AP-2, alpha 1 subunit
IDBP-628101
adaptor protein complex AP-2, alpha 1 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196961:
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44900373-44929496
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000085399 ENSMUSP00000082519
ENSMUST00000107857 ENSMUSP00000103489
ENSMUST00000166972 ENSMUSP00000127842
ENSMUST00000170656
ENSMUST00000165890 ENSMUSP00000133013
ENSMUST00000164575 ENSMUSP00000132374
ENSMUST00000166060
ENSMUST00000169527
ENSMUST00000168862 ENSMUSP00000131664
ENSMUST00000167675
ENSMUST00000167930 ENSMUSP00000127497
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008565 protein transporter activity
Biological Process
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:1900126 negative regulation of hyaluronan biosynthetic process
Cellular Component
GO:0005905 coated pit
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030117 membrane coat
GO:0030131 clathrin adaptor complex
GO:0030141 secretory granule
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196961
View Gene Order
ENSBTAG00000019180
Not yet available
Pathways
NETPATH
REACTOME
REACT_222404
WNT5A-dependent internalization of FZD4 pathway
REACT_203917
EGFR downregulation pathway
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_257923
Recycling pathway of L1 pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_232605
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
REACT_230745
Immune System pathway
REACT_202778
Retrograde neurotrophin signalling pathway
REACT_214043
PCP/CE pathway pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_242976
Signaling by EGFR pathway
REACT_261444
Axon guidance pathway
REACT_219680
L1CAM interactions pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_259290
Neuronal System pathway
REACT_188576
Developmental Biology pathway
REACT_253367
Trafficking of GluR2-containing AMPA receptors pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_188257
Signal Transduction pathway
REACT_244428
Trafficking of AMPA receptors pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_188180
Signaling by EGFR in Cancer pathway
KEGG
mmu05016
Huntington's disease pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_12435
Retrograde neurotrophin signalling pathway
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_11200
Nef Mediated CD8 Down-regulation pathway
REACT_11166
Nef Mediated CD4 Down-regulation pathway
REACT_18422
Trafficking of GluR2-containing AMPA receptors pathway
REACT_18307
Trafficking of AMPA receptors pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_172581
PCP/CE pathway pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_172599
WNT5A-dependent internalization of FZD4 pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_13685
Neuronal System pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_6185
HIV Infection pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_18347
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
REACT_116125
Disease pathway
KEGG
hsa04144
Endocytosis pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
arf_3pathway
Arf1 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.450396 Mm.6877
RefSeq NM_001077264 NM_007458 XM_006540569 XM_006540570
OMIM
CCDS CCDS52238 CCDS52239
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca