InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hoxd10

Summary

InnateDB Gene

IDBG-181043.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hoxd10

Gene Name

homeobox D10

Synonyms

AI385591; AI874987; Hox-4.5; Hox-5.3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000050368

Encoded Proteins

IDBP-181045

homeobox D10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128710:
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm\'s tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:74691924-74695105

Strand

Forward strand

Band

Transcripts

ENSMUST00000061745

ENSMUSP00000062412

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001501	skeletal system development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007338	single fertilization
GO:0007519	skeletal muscle tissue development
GO:0008344	adult locomotory behavior
GO:0009952	anterior/posterior pattern specification
GO:0009954	proximal/distal pattern formation
GO:0010468	regulation of gene expression
GO:0021520	spinal cord motor neuron cell fate specification
GO:0030326	embryonic limb morphogenesis
GO:0035136	forelimb morphogenesis
GO:0035137	hindlimb morphogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048704	embryonic skeletal system morphogenesis
GO:0048935	peripheral nervous system neuron development
GO:0050905	neuromuscular process

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000128710

View Gene Order

ENSBTAG00000016030

Not yet available

Cross-References

SwissProt

P28359

TrEMBL

UniProt Splice Variant

Entrez Gene

15430

UniGene

Mm.24420 Mm.397433

RefSeq

NM_013554 XM_006498789

OMIM

CCDS

CCDS16141

HPRD

IMGT

MGI ID

MGI:96202

MGI Symbol

Hoxd10

EMBL

BC013463 BC048690 X14715 X62669

GenPept

AAH13463 AAH48690 CAA44541 CAB57814

RNA Seq Atlas

15430