Version 5.4
Mus musculus Gene: Ampd1
Summary
InnateDB Gene IDBG-181090.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ampd1
Gene Name adenosine monophosphate deaminase 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000070385
Encoded Proteins
IDBP-181092
adenosine monophosphate deaminase 1
IDBP-715732
IDBP-717644
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116748:
Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:103074014-103099714
Strand Forward strand
Band F2.2
Transcripts
ENSMUST00000090715 ENSMUSP00000088217
ENSMUST00000155034
ENSMUST00000176440 ENSMUSP00000135737
ENSMUST00000177250 ENSMUSP00000134772
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003876 AMP deaminase activity
GO:0019239 deaminase activity
GO:0032036 myosin heavy chain binding
GO:0046872 metal ion binding
Biological Process
GO:0006188 IMP biosynthetic process
GO:0010033 response to organic substance
GO:0032264 IMP salvage
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116748
View Gene Order
ENSBTAG00000011548
Not yet available
Pathways
NETPATH
REACTOME
REACT_263730
Purine metabolism pathway
REACT_188937
Metabolism pathway
REACT_244050
Purine salvage pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
mmu00230
Purine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1923
Purine salvage pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt Q3V1D3
TrEMBL H3BLC7
UniProt Splice Variant
Entrez Gene 229665
UniGene Mm.331272
RefSeq NM_001033303 XM_006501400 XM_006501401
OMIM
CCDS CCDS38571
HPRD
IMGT
MGI ID MGI:88015
MGI Symbol Ampd1
EMBL AC150894 AC163297 AK132524
GenPept BAE21218
RNA Seq Atlas 229665

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca