Version 5.4
Homo sapiens Gene: SERPINA10
Summary
InnateDB Gene IDBG-18111.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINA10
Gene Name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140093
Encoded Proteins
IDBP-18113
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
IDBP-244312
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
IDBP-584545
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
IDBP-587251
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:94280455-94293271
Strand Reverse strand
Band q32.13
Transcripts
ENST00000261994 ENSP00000261994
ENST00000393096 ENSP00000376809
ENST00000554723 ENSP00000450896
ENST00000554173 ENSP00000450971
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0008201 heparin binding
Biological Process
GO:0007596 blood coagulation
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061947
View Gene Order
ENSBTAG00000009894
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.118620
RefSeq NM_001100607 NM_016186 XM_005267733 XM_006720159 XM_006725163 XM_006725164
HUGO
OMIM
CCDS CCDS9923
HPRD 09245
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca