Version 5.4
Mus musculus Gene: Fxyd4
Summary
InnateDB Gene IDBG-181236.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fxyd4
Gene Name FXYD domain-containing ion transport regulator 4
Synonyms 0610008I02Rik; AI267073; Chif
Species Mus musculus
Ensembl Gene ENSMUSG00000004988
Encoded Proteins
IDBP-181238
FXYD domain-containing ion transport regulator 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:117933729-117937335
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000005114 ENSMUSP00000005114
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0051117 ATPase binding
Biological Process
GO:0006811 ion transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_250224
Ion transport by P-type ATPases pathway
KEGG
mmu04960
Aldosterone-regulated sodium reabsorption pathway
INOH
PID NCI
Cross-References
SwissProt Q9D2W0
TrEMBL
UniProt Splice Variant
Entrez Gene 108017
UniGene
RefSeq NM_001173372 NM_033648 XM_006505289 XM_006505295
OMIM
CCDS CCDS20468
HPRD
IMGT
MGI ID MGI:1889005
MGI Symbol Fxyd4
EMBL AF362729 AK018728 BC086918
GenPept AAH86918 AAK51508 BAB31372
RNA Seq Atlas 108017

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca