Version 5.4
Homo sapiens Gene: KLRF1
Summary
InnateDB Gene IDBG-18125.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLRF1
Gene Name killer cell lectin-like receptor subfamily F, member 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000150045
Encoded Proteins
IDBP-18131
killer cell lectin-like receptor subfamily F, member 1
IDBP-18133
killer cell lectin-like receptor subfamily F, member 1
IDBP-585219
killer cell lectin-like receptor subfamily F, member 1
IDBP-596193
killer cell lectin-like receptor subfamily F, member 1
IDBP-809661
killer cell lectin-like receptor subfamily F, member 1
IDBP-809663
killer cell lectin-like receptor subfamily F, member 1
IDBP-809674
killer cell lectin-like receptor subfamily F, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:9827481-9845007
Strand Forward strand
Band p13.31
Transcripts
ENST00000354855 ENSP00000346919
ENST00000279545 ENSP00000279545
ENST00000545196 ENSP00000445022
ENST00000537723 ENSP00000443054
ENST00000617889 ENSP00000483713
ENST00000612321 ENSP00000483880
ENST00000616259
ENST00000617793 ENSP00000484826
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0030246 carbohydrate binding
GO:0032393 MHC class I receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL Q4KMZ4
UniProt Splice Variant
Entrez Gene 51348
UniGene
RefSeq NM_001291822 NM_001291823 NM_016523
HUGO HGNC:13342
OMIM 605029
CCDS CCDS41750
HPRD
IMGT
EMBL BC098257
GenPept AAH98257
RNA Seq Atlas 51348

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca