Version 5.4
Mus musculus Gene: Llgl1
Summary
InnateDB Gene IDBG-181336.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Llgl1
Gene Name lethal giant larvae homolog 1 (Drosophila)
Synonyms AI325176; Lgl1; Llglh; Mgl1
Species Mus musculus
Ensembl Gene ENSMUSG00000020536
Encoded Proteins
IDBP-181338
lethal giant larvae homolog 1 (Drosophila)
IDBP-263941
lethal giant larvae homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131899:
This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:60699723-60714186
Strand Forward strand
Band B2
Transcripts
ENSMUST00000052346 ENSMUSP00000060749
ENSMUST00000108719 ENSMUSP00000104359
ENSMUST00000128749
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005097 Rab GTPase activator activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0006461 protein complex assembly
GO:0006887 exocytosis
GO:0006893 Golgi to plasma membrane transport
GO:0007409 axonogenesis
GO:0007420 brain development
GO:0030866 cortical actin cytoskeleton organization
GO:0032851 positive regulation of Rab GTPase activity
GO:0035090 maintenance of apical/basal cell polarity
Cellular Component
GO:0000137 Golgi cis cisterna
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0030424 axon
GO:0030864 cortical actin cytoskeleton
GO:0031901 early endosome membrane
GO:0032588 trans-Golgi network membrane
GO:0035748 myelin sheath abaxonal region
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000131899
View Gene Order
ENSBTAG00000004635
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04530
Tight junction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.285453
RefSeq NM_001159404 NM_001159405 NM_008502 XM_006532354 XM_006532355
OMIM
CCDS CCDS48812 CCDS48813
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca