Version 5.4
Homo sapiens Gene: SERPINA6
Summary
InnateDB Gene IDBG-18137.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINA6
Gene Name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Synonyms CBG
Species Homo sapiens
Ensembl Gene ENSG00000170099
Encoded Proteins
IDBP-18139
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
IDBP-590883
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
IDBP-596180
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:94304248-94323394
Strand Reverse strand
Band q32.13
Transcripts
ENST00000341584 ENSP00000342850
ENST00000555056 ENSP00000451045
ENST00000557225 ENSP00000452018
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005496 steroid binding
Biological Process
GO:0006810 transport
GO:0008211 glucocorticoid metabolic process
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000060807
View Gene Order
ENSBTAG00000039808
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.532635
RefSeq NM_001756
HUGO
OMIM
CCDS CCDS9924
HPRD 00419
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca