InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trim26

Summary

InnateDB Gene

IDBG-181584.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim26

Gene Name

tripartite motif-containing 26

Synonyms

AI462198; Zfp173; Zfp1736

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024457

Encoded Proteins

IDBP-181586

tripartite motif-containing 26

IDBP-535033

tripartite motif-containing 26

IDBP-539335

tripartite motif-containing 26

IDBP-533943

tripartite motif-containing 26

IDBP-536232

tripartite motif-containing 26

IDBP-535035

tripartite motif-containing 26

IDBP-713426

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23438823

[Homo sapiens] TRIM26 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000234127:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:36837134-36859398

Strand

Forward strand

Band

Transcripts

ENSMUST00000053434	ENSMUSP00000060103
ENSMUST00000124307
ENSMUST00000134325
ENSMUST00000130367	ENSMUSP00000114896
ENSMUST00000130801	ENSMUSP00000118388
ENSMUST00000144182	ENSMUSP00000114565
ENSMUST00000123715	ENSMUSP00000118438
ENSMUST00000124136	ENSMUSP00000120764
ENSMUST00000156872
ENSMUST00000179968	ENSMUSP00000136651

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0045087	innate immune response
GO:0046597	negative regulation of viral entry into host cell
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000234127

View Gene Order

ENSBTAG00000035744

Not yet available

Cross-References

SwissProt

Q99PN3

TrEMBL

B8JJ57

UniProt Splice Variant

Entrez Gene

22670

UniGene

Mm.34587

RefSeq

NM_001025599 NM_001286726 NM_001286727 XM_006524213 XM_006524214 XM_006536594 XM_006536595 XM_006536596 XM_006536835 XM_006536836 XM_006537326 XM_006537327 XM_006537328

OMIM

CCDS

CCDS37613

HPRD

IMGT

MGI ID

MGI:1337056

MGI Symbol

Trim26

EMBL

AF230395 AF230396 AK042252 BC037110 CH466559 CR956641

GenPept

AAG50174 AAG50175 AAH37110 BAC31204 CAX15648 EDL23302

RNA Seq Atlas

22670