Version 5.4
Mus musculus Gene: Trim15
Summary
InnateDB Gene IDBG-181673.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trim15
Gene Name tripartite motif-containing 15
Synonyms 1810012B10Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000050747
Encoded Proteins
IDBP-181675
tripartite motif-containing 15
IDBP-622051
tripartite motif-containing 15
IDBP-622052
tripartite motif-containing 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23077300
[Homo sapiens] TRIM15 is required for RIG-I mediated interferon production to inhibit viral replication.
PMID 23438823
[Homo sapiens] TRIM15 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204610:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:36860691-36867210
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000025329 ENSMUSP00000025329
ENSMUST00000174195 ENSMUSP00000133953
ENSMUST00000173639 ENSMUSP00000133638
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0032481 positive regulation of type I interferon production
GO:0045087 innate immune response
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:1900246 positive regulation of RIG-I signaling pathway
GO:1901253 negative regulation of intracellular transport of viral material
GO:1902187 negative regulation of viral release from host cell
Cellular Component
GO:0005575 cellular_component
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000204610
View Gene Order
ENSBTAG00000007532
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.307027
RefSeq NM_001024134 NM_001177872
OMIM
CCDS CCDS50102 CCDS57079
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca