Homo sapiens Gene: SERPINA1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-18174.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | SERPINA1 | ||||||||||||||||||||||
Gene Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | ||||||||||||||||||||||
Synonyms | A1A; A1AT; AAT; alpha1AT; PI; PI1; PRO2275 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000197249 | ||||||||||||||||||||||
Encoded Proteins |
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 14:94376747-94390693 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q32.13 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Platelet activation, signaling and aggregation pathway
Hemostasis pathway
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KEGG |
Complement and coagulation cascades pathway
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INOH | |||||||||||||||||||||||
PID NCI |
p73 transcription factor network
FOXA1 transcription factor network
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.525557 | ||||||||||||||||||||||
RefSeq | NM_000295 NM_001002235 NM_001002236 NM_001127700 NM_001127701 NM_001127702 NM_001127703 NM_001127704 NM_001127705 NM_001127706 NM_001127707 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS9925 | ||||||||||||||||||||||
HPRD | 02463 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||