InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Myo1e

Summary

InnateDB Gene

IDBG-182044.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo1e

Gene Name

myosin IE

Synonyms

2310020N23Rik; 9130023P14Rik; AA407778; myosin-1e; myr 3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032220

Encoded Proteins

IDBP-182046

myosin IE

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157483:
This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:70207350-70400067

Strand

Forward strand

Band

Transcripts

ENSMUST00000034745

ENSMUSP00000034745

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0035091	phosphatidylinositol binding
GO:0042623	ATPase activity, coupled
GO:0051015	actin filament binding

Biological Process

GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0001822	kidney development
GO:0003094	glomerular filtration
GO:0006200	ATP catabolic process
GO:0006807	nitrogen compound metabolic process
GO:0006897	endocytosis
GO:0030097	hemopoiesis
GO:0032836	glomerular basement membrane development
GO:0035166	post-embryonic hemopoiesis
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0072015	glomerular visceral epithelial cell development

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0016459	myosin complex
GO:0045334	clathrin-coated endocytic vesicle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000157483

View Gene Order

ENSBTAG00000021538

Not yet available

Cross-References

SwissProt

E9Q634

TrEMBL

Q3TLJ4

UniProt Splice Variant

Entrez Gene

71602

UniGene

Mm.249311 Mm.465834

RefSeq

NM_181072

OMIM

CCDS

CCDS40680

HPRD

IMGT

MGI ID

MGI:106621

MGI Symbol

Myo1e

EMBL

AC157086 AC157950 AC157996 AF426465 AK166477 BC051391

GenPept

AAH51391 AAL26545 BAE38798

RNA Seq Atlas

71602