Version 5.4
Mus musculus Gene: Pmch
Summary
InnateDB Gene IDBG-183088.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pmch
Gene Name pro-melanin-concentrating hormone
Synonyms A230109K23Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000035383
Encoded Proteins
IDBP-183090
pro-melanin-concentrating hormone
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a preproprotein that is cleaved to produce three mature peptides: melanin concentrating hormone, neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). The proprotein is processed differently depending on the tissue where it is expressed. Melanin concentrating hormone is involved in the regulation of food intake, energy homeostasis, and sleep-wake behavior. Disruption of this gene is associated with resistance to diet-induced obesity. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:88091072-88092375
Strand Forward strand
Band C1
Transcripts
ENSMUST00000048621 ENSMUSP00000044352
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0030354 melanin-concentrating hormone activity
Biological Process
GO:0007218 neuropeptide signaling pathway
GO:0007268 synaptic transmission
GO:0007631 feeding behavior
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000183395
View Gene Order
ENSBTAG00000013008
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_231468
GPCR ligand binding pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P56942
TrEMBL
UniProt Splice Variant
Entrez Gene 110312
UniGene
RefSeq NM_029971
OMIM
CCDS CCDS24105
HPRD
IMGT
MGI ID MGI:97629
MGI Symbol Pmch
EMBL AC139754 AK020723 AK138363 CH466539
GenPept BAB32189 BAE23633 EDL21464
RNA Seq Atlas 110312

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca