Mus musculus Gene: Olfm4 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||
InnateDB Gene | IDBG-183156.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Olfm4 | ||||||||||
Gene Name | olfactomedin 4 | ||||||||||
Synonyms | |||||||||||
Species | Mus musculus | ||||||||||
Ensembl Gene | ENSMUSG00000022026 | ||||||||||
Encoded Proteins |
olfactomedin 4
|
||||||||||
Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
InnateDB Annotation | |||||||||||
Summary |
Olfm4 is a negative regulator of neutrophil bactericidal activity by restricting cathepsin C-mediated protease activities.
|
||||||||||
InnateDB Annotation from Orthologs | |||||||||||
Summary |
[Homo sapiens] OLFM4 exerts considerable influence on the host defence against H. pylori infection acting through NOD1 and NOD2 mediated NF-kappaB activation and subsequent cytokines and chemokines production, which in turn inhibit host immune response and contribute to persistence of H. pylori colonization.
[Homo sapiens] OLFM4 is a negative regulator of neutrophil bactericidal activity by restricting cathepsin C-mediated protease activities. (Demonstrated in mice)
|
||||||||||
Entrez Gene | |||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102837:
This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011] |
||||||||||
Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome 14:80000302-80021930 | ||||||||||
Strand | Forward strand | ||||||||||
Band | D3 | ||||||||||
Transcripts |
|
||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
|
||||||||||
Gene Ontology | |||||||||||
Molecular Function |
|
||||||||||
Biological Process |
|
||||||||||
Cellular Component |
|
||||||||||
Orthologs | |||||||||||
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||
Cross-References | |||||||||||
SwissProt | |||||||||||
TrEMBL | D3YYD0 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 380924 | ||||||||||
UniGene | |||||||||||
RefSeq | NM_001030294 | ||||||||||
OMIM | |||||||||||
CCDS | CCDS36989 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
MGI ID | MGI:2685142 | ||||||||||
MGI Symbol | Olfm4 | ||||||||||
EMBL | AC146609 | ||||||||||
GenPept | |||||||||||
RNA Seq Atlas | 380924 | ||||||||||