Version 5.4
Mus musculus Gene: Diap3
Summary
InnateDB Gene IDBG-183244.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Diap3
Gene Name diaphanous homolog 3 (Drosophila)
Synonyms 4930417P13Rik; Dia2; Diaph3; Drf3; mDia2; mKIAA4117; p134MDia2
Species Mus musculus
Ensembl Gene ENSMUSG00000022021
Encoded Proteins
IDBP-183246
diaphanous homolog 3 (Drosophila)
IDBP-620537
diaphanous homolog 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139734:
This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:86655367-87141224
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000022599 ENSMUSP00000022599
ENSMUST00000168889 ENSMUSP00000129420
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005488 binding
GO:0017048 Rho GTPase binding
Biological Process
GO:0007283 spermatogenesis
GO:0016043 cellular component organization
GO:0030036 actin cytoskeleton organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000139734
View Gene Order
ENSBTAG00000012443
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
cdc42_pathway
CDC42 signaling events
Cross-References
SwissProt Q9Z207
TrEMBL Q3TSX1 Q3UU77 Q3UVP0
UniProt Splice Variant
Entrez Gene 56419
UniGene Mm.410740 Mm.440585
RefSeq NM_019670
OMIM
CCDS CCDS36990
HPRD
IMGT
MGI ID MGI:1927222
MGI Symbol Diap3
EMBL AF094519 AK137073 AK138694 AK161737
GenPept AAC71771 BAE23229 BAE23751 BAE36554
RNA Seq Atlas 56419

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca