Version 5.4
Mus musculus Gene: Kcnd3
Summary
InnateDB Gene IDBG-183598.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnd3
Gene Name potassium voltage-gated channel, Shal-related family, member 3
Synonyms AW045978; Kncd3; Kv4.3
Species Mus musculus
Ensembl Gene ENSMUSG00000040896
Encoded Proteins
IDBP-183600
potassium voltage-gated channel, Shal-related family, member 3
IDBP-183602
potassium voltage-gated channel, Shal-related family, member 3
IDBP-400625
potassium voltage-gated channel, Shal-related family, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171385:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:105452330-105674002
Strand Forward strand
Band F2.2
Transcripts
ENSMUST00000098761 ENSMUSP00000096357
ENSMUST00000079169 ENSMUSP00000078169
ENSMUST00000118360 ENSMUSP00000113436
ENSMUST00000141694
ENSMUST00000147209
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005250 A-type (transient outward) potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0044325 ion channel binding
GO:0046872 metal ion binding
Biological Process
GO:0006811 ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071435 potassium ion export
GO:0086009 membrane repolarization
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0030425 dendrite
GO:0042383 sarcolemma
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0097038 perinuclear endoplasmic reticulum
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171385
View Gene Order
ENSBTAG00000031654
Not yet available
Pathways
NETPATH
REACTOME
REACT_202800
Potassium Channels pathway
REACT_259290
Neuronal System pathway
REACT_199077
Voltage gated Potassium channels pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75770
Voltage gated Potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9Z0V1
TrEMBL B2RUE0
UniProt Splice Variant
Entrez Gene 56543
UniGene Mm.44530
RefSeq NM_019931 NM_001039347 XM_006501755 XM_006501756
OMIM
CCDS CCDS17709 CCDS17708
HPRD
IMGT
MGI ID MGI:1928743
MGI Symbol Kcnd3
EMBL AF107781 AF107782 AK033962 BC141097 BC141098 CH466608
GenPept AAD16973 AAD16974 AAI41098 AAI41099 BAC28529 EDL07552
RNA Seq Atlas 56543

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca