InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp6v1e1

Summary

InnateDB Gene

IDBG-183944.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v1e1

Gene Name

ATPase, H+ transporting, lysosomal V1 subunit E1

Synonyms

2410029D23Rik; Atp6e; Atp6e2; Atp6v1e; D6Ertd385e; E2; P31; Vma4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019210

Encoded Proteins

IDBP-183946

ATPase, H+ transporting, lysosomal V1 subunit E1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131100:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:120795245-120822685

Strand

Reverse strand

Band

Transcripts

ENSMUST00000019354

ENSMUSP00000019354

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0046961	proton-transporting ATPase activity, rotational mechanism
GO:0051117	ATPase binding

Biological Process

GO:0008152	metabolic process
GO:0015991	ATP hydrolysis coupled proton transport

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005829	cytosol
GO:0005902	microvillus
GO:0016324	apical plasma membrane
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain
GO:0070062	extracellular vesicular exosome