InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cnot1

Summary

InnateDB Gene

IDBG-184242.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cnot1

Gene Name

CCR4-NOT transcription complex, subunit 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036550

Encoded Proteins

IDBP-184244

CCR4-NOT transcription complex, subunit 1

IDBP-184246

CCR4-NOT transcription complex, subunit 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125107:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:95719451-95807462

Strand

Reverse strand

Band

Transcripts

ENSMUST00000068452	ENSMUSP00000063565
ENSMUST00000098473	ENSMUSP00000096073

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005488	binding
GO:0005515	protein binding
GO:0030331	estrogen receptor binding
GO:0042974	retinoic acid receptor binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001829	trophectodermal cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006417	regulation of translation
GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly
GO:0031047	gene silencing by RNA
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway
GO:0048387	negative regulation of retinoic acid receptor signaling pathway
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2000036	regulation of stem cell maintenance

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005778	peroxisomal membrane
GO:0016020	membrane
GO:0030014	CCR4-NOT complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000125107

View Gene Order

ENSBTAG00000020782

Not yet available

Pathways

NETPATH

REACTOME

REACT_244119

Deadenylation of mRNA pathway

REACT_233572

Gene Expression pathway

REACT_235784

Deadenylation-dependent mRNA decay pathway

KEGG

mmu03018

RNA degradation pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_20514

Deadenylation of mRNA pathway

REACT_20639

Deadenylation-dependent mRNA decay pathway

REACT_71

Gene Expression pathway

KEGG

hsa03018

RNA degradation pathway

INOH

PID NCI

Cross-References

SwissProt

Q6ZQ08

TrEMBL

B7ZWL1

UniProt Splice Variant

Entrez Gene

620499

UniGene

Mm.259220 Mm.415682

RefSeq

NM_001205226 NM_153164 NM_178078 XM_006519750 XM_006530870 XM_006530871 XM_006530872 XM_006530873 XM_006530874 XM_006530875 XM_006543124

OMIM

CCDS

CCDS57635

HPRD

IMGT

MGI ID

MGI:2442402

MGI Symbol

Cnot1

EMBL

AC113951 AC127300 AK031357 AK034776 AK048177 AK129258 AK143651 BC018281 BC158073 BC172105

GenPept

AAH18281 AAI58074 AAI72105 BAC27364 BAC28830 BAC33267 BAC98068 BAE25479

RNA Seq Atlas

234594 620499