Version 5.4
Mus musculus Gene: Itgav
Summary
InnateDB Gene IDBG-184247.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itgav
Gene Name integrin alpha V
Synonyms 1110004F14Rik; 2610028E01Rik; CD51; D430040G12Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000027087
Encoded Proteins
IDBP-184249
integrin alpha V
IDBP-257478
integrin alpha V
IDBP-532757
integrin alpha V
IDBP-534255
integrin alpha V
IDBP-532820
integrin alpha V
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23150579
[Homo sapiens] ITGAV::ITGB3 is a sensor and activator of innate immunity to herpes simplex virus-1.
Entrez Gene
Summary This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 1, beta 3, beta 6 and beta 8. The heterodimer of alpha v and beta 3 forms the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. In mouse, deficiency of this gene is associated with defects in vascular morphogenesis in the brain and early post-natal death. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:83724397-83806916
Strand Forward strand
Band D
Transcripts
ENSMUST00000028499 ENSMUSP00000028499
ENSMUST00000111740 ENSMUSP00000107369
ENSMUST00000125360
ENSMUST00000141725 ENSMUSP00000122730
ENSMUST00000155521
ENSMUST00000151463
ENSMUST00000148256
ENSMUST00000125402 ENSMUSP00000118016
ENSMUST00000131192 ENSMUSP00000121295
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001846 opsonin binding
GO:0005080 protein kinase C binding
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
GO:0031994 insulin-like growth factor I binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0009566 fertilization
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010888 negative regulation of lipid storage
GO:0030335 positive regulation of cell migration
GO:0031589 cell-substrate adhesion
GO:0032369 negative regulation of lipid transport
GO:0032490 detection of molecule of bacterial origin
GO:0033690 positive regulation of osteoblast proliferation
GO:0035262 gonad morphogenesis
GO:0042110 T cell activation
GO:0043277 apoptotic cell clearance
GO:0043542 endothelial cell migration
GO:0045124 regulation of bone resorption
GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045785 positive regulation of cell adhesion
GO:0048041 focal adhesion assembly
GO:0050748 negative regulation of lipoprotein metabolic process
GO:0050764 regulation of phagocytosis
GO:0051209 release of sequestered calcium ion into cytosol
GO:0060707 trophoblast giant cell differentiation
GO:0070371 ERK1 and ERK2 cascade
GO:0070588 calcium ion transmembrane transport
GO:0071731 response to nitric oxide
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2000425 regulation of apoptotic cell clearance
GO:2000536 negative regulation of entry of bacterium into host cell
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0034683 alphav-beta3 integrin complex
GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138448
View Gene Order
ENSBTAG00000019929
Not yet available
Pathways
NETPATH
REACTOME
REACT_196644
Syndecan interactions pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_227951
Signaling by VEGF pathway
REACT_198996
Elastic fibre formation pathway
REACT_198998
Molecules associated with elastic fibres pathway
REACT_230745
Immune System pathway
REACT_206066
Extracellular matrix organization pathway
REACT_202342
Laminin interactions pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_199113
Antigen processing-Cross presentation pathway
REACT_199093
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
REACT_215461
Signal transduction by L1 pathway
REACT_219680
L1CAM interactions pathway
REACT_229531
Adaptive Immune System pathway
REACT_188576
Developmental Biology pathway
REACT_196606
ECM proteoglycans pathway
REACT_196607
Non-integrin membrane-ECM interactions pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04512
ECM-receptor interaction pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu05222
Small cell lung cancer pathway
mmu04510
Focal adhesion pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05200
Pathways in cancer pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
mmu04145
Phagosome pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111174
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
REACT_12519
PECAM1 interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_118779
Extracellular matrix organization pathway
REACT_12529
Signaling by VEGF pathway
REACT_163942
Syndecan interactions pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_163906
ECM proteoglycans pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_169262
Laminin interactions pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04512
ECM-receptor interaction pathway
hsa05222
Small cell lung cancer pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05200
Pathways in cancer pathway
hsa05414
Dilated cardiomyopathy pathway
hsa04145
Phagosome pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
avb3_integrin_pathway
Integrins in angiogenesis
integrin_cs_pathway
Integrin family cell surface interactions
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
nectin_pathway
Nectin adhesion pathway
fak_pathway
Signaling events mediated by focal adhesion kinase
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
integrin3_pathway
Beta3 integrin cell surface interactions
pdgfrapathway
PDGFR-alpha signaling pathway
integrin5_pathway
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
pdgfrbpathway
PDGFR-beta signaling pathway
avb3_opn_pathway
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL A2AKI5 Q80Y67
UniProt Splice Variant
Entrez Gene 16410
UniGene Mm.227 Mm.431734
RefSeq NM_008402 XM_006498807
OMIM
CCDS CCDS16181
HPRD
IMGT
MGI ID MGI:96608
MGI Symbol Itgav
EMBL AL772301 BC048857
GenPept AAH48857
RNA Seq Atlas 16410

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca