Version 5.4
Mus musculus Gene: Irg1
Summary
InnateDB Gene IDBG-184663.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irg1
Gene Name immunoresponsive gene 1
Synonyms AI323667; CAD
Species Mus musculus
Ensembl Gene ENSMUSG00000022126
Encoded Proteins
IDBP-184665
immunoresponsive gene 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102794:
Gene Information
Type Protein coding
Genomic Location Chromosome 14:103046977-103056573
Strand Forward strand
Band E2.3
Transcripts
ENSMUST00000022722 ENSMUSP00000022722
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0047547 2-methylcitrate dehydratase activity
GO:0047613 aconitate decarboxylase activity
Biological Process
GO:0002760 positive regulation of antimicrobial humoral response
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007566 embryo implantation
GO:0008152 metabolic process
GO:0019543 propionate catabolic process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032480 negative regulation of type I interferon production
GO:0032496 response to lipopolysaccharide
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0035458 cellular response to interferon-beta
GO:0045824 negative regulation of innate immune response
GO:0050728 negative regulation of inflammatory response
GO:0071219 cellular response to molecule of bacterial origin
GO:0071222 cellular response to lipopolysaccharide
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071393 cellular response to progesterone stimulus
GO:0072573 tolerance induction to lipopolysaccharide
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102794
View Gene Order
ENSBTAG00000008259
Not yet available
Cross-References
SwissProt P54987
TrEMBL
UniProt Splice Variant
Entrez Gene 16365
UniGene Mm.4662 Mm.475063
RefSeq NM_008392
OMIM
CCDS CCDS49558
HPRD
IMGT
MGI ID MGI:103206
MGI Symbol Irg1
EMBL AK036446 AK152177 AK152248 AK152332 AK152635 AK172001 AK172298 L38281
GenPept AAA74554 BAC29433 BAE31008 BAE31070 BAE31131 BAE31377 BAE42768 BAE42932
RNA Seq Atlas 16365

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca