Version 5.4
Mus musculus Gene: Cdh8
Summary
InnateDB Gene IDBG-184746.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdh8
Gene Name cadherin 8
Synonyms AI851472; cad8
Species Mus musculus
Ensembl Gene ENSMUSG00000036510
Encoded Proteins
IDBP-184748
cadherin 8
IDBP-538577
cadherin 8
IDBP-537667
cadherin 8
IDBP-534665
cadherin 8
IDBP-541684
cadherin 8
IDBP-534423
cadherin 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150394:
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008]
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein\'s homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:99024471-99416471
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000093249 ENSMUSP00000090935
ENSMUST00000155527 ENSMUSP00000123619
ENSMUST00000142129 ENSMUSP00000114507
ENSMUST00000128860 ENSMUSP00000117326
ENSMUST00000145601 ENSMUSP00000122493
ENSMUST00000126895
ENSMUST00000142475 ENSMUSP00000115977
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
GO:0007268 synaptic transmission
GO:0009409 response to cold
GO:0035249 synaptic transmission, glutamatergic
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043083 synaptic cleft
GO:0043679 axon terminus
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000150394
View Gene Order
Pathways
NETPATH
REACTOME
REACT_248094
Cell-cell junction organization pathway
REACT_230395
Adherens junctions interactions pathway
REACT_241978
Cell junction organization pathway
REACT_223082
Cell-Cell communication pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19195
Adherens junctions interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P97291
TrEMBL
UniProt Splice Variant
Entrez Gene 12564
UniGene Mm.441131 Mm.447030
RefSeq NM_007667 XM_006530631 NM_001039154 NM_001285913 NM_001285914 XM_006530632 XM_006530633
OMIM
CCDS CCDS40448 CCDS22569 CCDS72155 CCDS72156
HPRD
IMGT
MGI ID MGI:107434
MGI Symbol Cdh8
EMBL AC102643 AC103397 AC162519 AC162867 CH466525 X95600
GenPept CAA64857 EDL11191
RNA Seq Atlas 12564

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca