Version 5.4
Mus musculus Gene: Gemin8
Summary
InnateDB Gene IDBG-185202.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gemin8
Gene Name gem (nuclear organelle) associated protein 8
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000040621
Encoded Proteins
IDBP-181566
gem (nuclear organelle) associated protein 8
IDBP-185204
gem (nuclear organelle) associated protein 8
IDBP-193894
gem (nuclear organelle) associated protein 8
IDBP-532023
gem (nuclear organelle) associated protein 8
IDBP-626897
gem (nuclear organelle) associated protein 8
IDBP-626896
gem (nuclear organelle) associated protein 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000046647:
The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:166170454-166190512
Strand Forward strand
Band F5
Transcripts
ENSMUST00000087169 ENSMUSP00000084414
ENSMUST00000096252 ENSMUSP00000093971
ENSMUST00000056410 ENSMUSP00000085137
ENSMUST00000130880 ENSMUSP00000118482
ENSMUST00000152248 ENSMUSP00000131284
ENSMUST00000166440 ENSMUSP00000128502
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000387 spliceosomal snRNP assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032797 SMN complex
GO:0034719 SMN-Sm protein complex
GO:0097504 Gemini of coiled bodies
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000046647
View Gene Order
ENSBTAG00000010289
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03013
RNA transport pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt Q8BHE1
TrEMBL E9PZ44 E9QA54
UniProt Splice Variant
Entrez Gene 237221
UniGene Mm.209490 Mm.405272
RefSeq NM_146238 XM_006528838
OMIM
CCDS CCDS41207
HPRD
IMGT
MGI ID MGI:2384300
MGI Symbol Gemin8
EMBL AK047511 AK053774 AK160583 AL713990 BC023488
GenPept AAH23488 BAC33077 BAC35516 BAE35890 CAM17946
RNA Seq Atlas 237221

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca