InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Acvrl1

Summary

InnateDB Gene

IDBG-185502.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acvrl1

Gene Name

activin A receptor, type II-like 1

Synonyms

Acvrlk1; AI115505; AI427544; Alk1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000530

Encoded Proteins

IDBP-185504

activin A receptor, type II-like 1

IDBP-400817

activin A receptor, type II-like 1

IDBP-400814

activin A receptor, type II-like 1

IDBP-400816

activin A receptor, type II-like 1

IDBP-400815

activin A receptor, type II-like 1

IDBP-400812

activin A receptor, type II-like 1

IDBP-537503

activin A receptor, type II-like 1

IDBP-533614

activin A receptor, type II-like 1

IDBP-536749

activin A receptor, type II-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139567:
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:101128522-101145336

Strand

Forward strand

Band

Transcripts

ENSMUST00000000542	ENSMUSP00000000542
ENSMUST00000120028	ENSMUSP00000113297
ENSMUST00000117984	ENSMUSP00000113505
ENSMUST00000119063	ENSMUSP00000113536
ENSMUST00000121718	ENSMUSP00000114027
ENSMUST00000120754	ENSMUSP00000112490
ENSMUST00000144229	ENSMUSP00000115241
ENSMUST00000130432	ENSMUSP00000122998
ENSMUST00000124151	ENSMUSP00000114829
ENSMUST00000128868
ENSMUST00000128525

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005025	transforming growth factor beta receptor activity, type I
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016361	activin receptor activity, type I
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0046332	SMAD binding
GO:0046872	metal ion binding
GO:0048185	activin binding
GO:0050431	transforming growth factor beta binding

Biological Process

GO:0001525	angiogenesis
GO:0001701	in utero embryonic development
GO:0001937	negative regulation of endothelial cell proliferation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001946	lymphangiogenesis
GO:0001974	blood vessel remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007162	negative regulation of cell adhesion
GO:0007165	signal transduction
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008015	blood circulation
GO:0008217	regulation of blood pressure
GO:0008285	negative regulation of cell proliferation
GO:0010596	negative regulation of endothelial cell migration
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0030308	negative regulation of cell growth
GO:0030336	negative regulation of cell migration
GO:0030509	BMP signaling pathway
GO:0030513	positive regulation of BMP signaling pathway
GO:0032924	activin receptor signaling pathway
GO:0035313	wound healing, spreading of epidermal cells
GO:0042118	endothelial cell activation
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0045602	negative regulation of endothelial cell differentiation
GO:0045603	positive regulation of endothelial cell differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048514	blood vessel morphogenesis
GO:0051291	protein heterooligomerization
GO:0051895	negative regulation of focal adhesion assembly
GO:0060836	lymphatic endothelial cell differentiation
GO:0060840	artery development
GO:0060841	venous blood vessel development
GO:0061154	endothelial tube morphogenesis
GO:0061298	retina vasculature development in camera-type eye
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0071773	cellular response to BMP stimulus
GO:2000279	negative regulation of DNA biosynthetic process