Mus musculus Gene: Tlr8 | |||||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-185523.6 | ||||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||
Gene Symbol | Tlr8 | ||||||||||||||||||||||||||||||||||||||
Gene Name | toll-like receptor 8 | ||||||||||||||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000040522 | ||||||||||||||||||||||||||||||||||||||
Encoded Proteins |
toll-like receptor 8
toll-like receptor 8
toll-like receptor 8
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Protein Structure | |||||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||||||||||||
Summary |
Tlr7 and Tlr8 are translocated from the endoplasmic reticulum to the endosome in the presence of antiphospholipid antibodies, as a consequence, plasmacytoid dendritic cells become dramatically sensitized to Tlr7/8 agonists and this may play a role in systemic autoimmunity.
Tlr8 binding of HIV ssRNA induces endosomal acidification and chromatin remodeling at the TNF-alpha promoter to promote TNF-alpha release in infected macrophages. (Demonstrated in human)
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||
Summary |
[Homo sapiens] TLR8 expression and function is highly up-regulated in colonic epithelium from patients with active inflammatory bowel disease (IBD), suggesting that TLR8 signalling is important in the pathogenesis of IBD.
[Homo sapiens] Toll-like receptor 8 (TLR8), 7 and 9 form a functional subgroup within the TLR family that recognizes pathogen-associated molecular patterns in endosomal/lysosomal compartments.
[Homo sapiens] TLR8 and TLR7 bind single-stranded RNA, stimulating dendritic cells (DCs) and macrophages to secrete interferon-alpha and pro-inflammatory, as well as regulatory, cytokines.
[Homo sapiens] TLR8 signalling strongly promotes inflammatory lipid mediator biosynthesis, providing novel insights on innate immune response to viral infections.
[Homo sapiens] TLR8 is activated in human monocytic cells following Helicobacter pylori phagocytosis and TLR8 single nucleotide polymorphism play a role in the modulation of TLR8-dependent microbicidal response of infected macrophages.
[Homo sapiens] TLR7 and TLR8 are translocated from the endoplasmic reticulum to the endosome in the presence of antiphospholipid antibodies, as a consequence, plasmacytoid dendritic cells become dramatically sensitized to TLR7/8 agonists and this may play a role in systemic autoimmunity.
[Homo sapiens] TLR8 binding of HIV ssRNA induces endosomal acidification and chromatin remodeling at the TNF-alpha promoter to promote TNF-alpha release in infected macrophages.
[Homo sapiens] TLR8 binds to exosomal MIR21 and MIR29A secreted by tumour cells and initiates a prometastatic inflammatory response.
[Homo sapiens] TLR8 plays a pathogenic role in disease whereby its expression is increased in patients with systemic arthritis and is correlated with the elevation of IL1B levels and disease status.
[Homo sapiens] TLR8 binds degradation products of single-stranded RNA at two distinct sites. One site prefers uridine mononucleosides and the other site prefers short oligonucleotides.
[Homo sapiens] TLR8-dependent detection of bacterial RNA is critical for triggering monocyte activation in response to infection with Streptococcus pyogenes.
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Entrez Gene | |||||||||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101916:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome X:167242696-167264329 | ||||||||||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||
Band | F5 | ||||||||||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||||
Species
Homo sapiens
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||||||
REACTOME |
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Innate Immune System pathway
Trafficking and processing of endosomal TLR pathway
Immune System pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll-Like Receptors Cascades pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
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KEGG |
Toll-like receptor signaling pathway pathway
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INOH | |||||||||||||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||||||
REACTOME |
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Trafficking and processing of endosomal TLR pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
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KEGG |
Toll-like receptor signaling pathway pathway
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INOH | |||||||||||||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||||||||||||
SwissProt | P58682 | ||||||||||||||||||||||||||||||||||||||
TrEMBL | A2AHI8 | ||||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||
Entrez Gene | 170744 | ||||||||||||||||||||||||||||||||||||||
UniGene | Mm.196676 | ||||||||||||||||||||||||||||||||||||||
RefSeq | NM_133212 XM_006528717 XM_006528718 XM_006528719 | ||||||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||||||
CCDS | CCDS41209 | ||||||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||||
MGI ID | MGI:2176887 | ||||||||||||||||||||||||||||||||||||||
MGI Symbol | Tlr8 | ||||||||||||||||||||||||||||||||||||||
EMBL | AL731735 AY035890 BC132054 | ||||||||||||||||||||||||||||||||||||||
GenPept | AAI32055 AAK62677 CAM14949 | ||||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | 170744 | ||||||||||||||||||||||||||||||||||||||