InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prps2

Summary

InnateDB Gene

IDBG-185554.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prps2

Gene Name

phosphoribosyl pyrophosphate synthetase 2

Synonyms

2610101M19Rik; AA589463; AI464149; Prps-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025742

Encoded Proteins

IDBP-185556

phosphoribosyl pyrophosphate synthetase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101911:
This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:167346322-167382749

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026839	ENSMUSP00000026839
ENSMUST00000145456

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004749	ribose phosphate diphosphokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016208	AMP binding
GO:0016301	kinase activity
GO:0019003	GDP binding
GO:0030246	carbohydrate binding
GO:0042803	protein homodimerization activity
GO:0043531	ADP binding

Biological Process

GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process
GO:0006167	AMP biosynthetic process
GO:0009116	nucleoside metabolic process
GO:0009165	nucleotide biosynthetic process
GO:0016310	phosphorylation
GO:0019693	ribose phosphate metabolic process
GO:0031100	organ regeneration