Version 5.4
Mus musculus Gene: Abcg3
Summary
InnateDB Gene IDBG-185682.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Abcg3
Gene Name ATP-binding cassette, sub-family G (WHITE), member 3
Synonyms Abcp2; Mxr2
Species Mus musculus
Ensembl Gene ENSMUSG00000029299
Encoded Proteins
IDBP-185684
ATP-binding cassette, sub-family G (WHITE), member 3
IDBP-533046
ATP-binding cassette, sub-family G (WHITE), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It lacks several highly conserved residues found in other ATP-binding proteins; this suggests that this protein may not bind ATP and may require dimerization with another subunit to form a functional ATP-transporter. The function of this gene has not yet been determined; however, high levels of expression in the thymus and spleen suggest a potential role in the transport of specific peptides or hydrophobic compounds from lymphocytes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:104935057-104982718
Strand Reverse strand
Band E5
Transcripts
ENSMUST00000031239 ENSMUSP00000031239
ENSMUST00000130644 ENSMUSP00000120179
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005524 ATP binding
GO:0016887 ATPase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_205755
Iron uptake and transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
mmu02010
ABC transporters pathway
INOH
PID NCI
Cross-References
SwissProt Q99P81
TrEMBL D3Z0Z4
UniProt Splice Variant
Entrez Gene 27405
UniGene Mm.389663 Mm.399628
RefSeq NM_030239 XM_006534963
OMIM
CCDS CCDS19488
HPRD
IMGT
MGI ID MGI:1351624
MGI Symbol Abcg3
EMBL AC125005 AF324242 AK051880 BC138772 BC138773 CH466529
GenPept AAI38773 AAI38774 AAK14241 BAC34799 EDL20215
RNA Seq Atlas 27405

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca