Version 5.4
Mus musculus Gene: Serpinb2
Summary
InnateDB Gene IDBG-186363.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Serpinb2
Gene Name serine (or cysteine) peptidase inhibitor, clade B, member 2
Synonyms ovalbumin; PAI-2; Planh2
Species Mus musculus
Ensembl Gene ENSMUSG00000062345
Encoded Proteins
IDBP-186365
serine (or cysteine) peptidase inhibitor, clade B, member 2
IDBP-186367
serine (or cysteine) peptidase inhibitor, clade B, member 2
IDBP-540745
serine (or cysteine) peptidase inhibitor, clade B, member 2
IDBP-538229
serine (or cysteine) peptidase inhibitor, clade B, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23472114
LPS stimulation promotes the formation of CEBPB complexes on the Serpinb2 promoter to drive transcription.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197632:
Gene Information
Type Protein coding
Genomic Location Chromosome 1:107511423-107535478
Strand Forward strand
Band E2.1
Transcripts
ENSMUST00000009356 ENSMUSP00000009356
ENSMUST00000064916 ENSMUSP00000065277
ENSMUST00000143832 ENSMUSP00000114751
ENSMUST00000146597 ENSMUSP00000119795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
GO:0042060 wound healing
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000197632
View Gene Order
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_235291
Dissolution of Fibrin Clot pathway
KEGG
mmu05146
Amoebiasis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_641
Dissolution of Fibrin Clot pathway
REACT_604
Hemostasis pathway
KEGG
hsa05146
Amoebiasis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 18788
UniGene Mm.271870 Mm.405450
RefSeq NM_001174170 NM_011111
OMIM
CCDS CCDS15219
HPRD
IMGT
MGI ID MGI:97609
MGI Symbol Serpinb2
EMBL
GenPept
RNA Seq Atlas 18788

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca