Version 5.4
Mus musculus Gene: Gsta2
Summary
InnateDB Gene IDBG-186640.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gsta2
Gene Name glutathione S-transferase, alpha 2 (Yc2)
Synonyms Gst2-2; Gstc-2; Gstc2
Species Mus musculus
Ensembl Gene ENSMUSG00000057933
Encoded Proteins
IDBP-186642
glutathione S-transferase, alpha 2 (Yc2)
IDBP-534104
glutathione S-transferase, alpha 2 (Yc2)
IDBP-535270
glutathione S-transferase, alpha 2 (Yc2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000243955:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008]
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual\'s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:78331018-78355788
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000034902 ENSMUSP00000034902
ENSMUST00000125479 ENSMUSP00000115517
ENSMUST00000129247 ENSMUSP00000117101
ENSMUST00000140498
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004364 glutathione transferase activity
GO:0005515 protein binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0008152 metabolic process
GO:0035634 response to stilbenoid
Cellular Component
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000243955
View Gene Order
Pathways
NETPATH
REACTOME
REACT_243247
Phase II conjugation pathway
REACT_188937
Metabolism pathway
REACT_215316
Glutathione conjugation pathway
REACT_232343
Biological oxidations pathway
KEGG
mmu00480
Glutathione metabolism pathway
mmu00980
Metabolism of xenobiotics by cytochrome P450 pathway
mmu00982
Drug metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6926
Glutathione conjugation pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00480
Glutathione metabolism pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00982
Drug metabolism pathway
INOH
PID NCI
Cross-References
SwissProt P10648
TrEMBL D3YZV3 D3Z6A6
UniProt Splice Variant
Entrez Gene 14858
UniGene Mm.422778
RefSeq NM_008182 XM_006510814
OMIM
CCDS CCDS23359
HPRD
IMGT
MGI ID MGI:95863
MGI Symbol Gsta2
EMBL AC138587 BC061133 CH466522 J03958
GenPept AAA37749 AAH61133 EDL26384 EDL26385 EDL26386 EDL26387
RNA Seq Atlas 14858

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca