Version 5.4
Mus musculus Gene: Krt5
Summary
InnateDB Gene IDBG-186662.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Krt5
Gene Name keratin 5
Synonyms 3300001P10Rik; AW146334; CK5; K5; Krt2-5; Tfip8
Species Mus musculus
Ensembl Gene ENSMUSG00000061527
Encoded Proteins
IDBP-186664
keratin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186081:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:101707070-101712891
Strand Reverse strand
Band F2
Transcripts
ENSMUST00000023709 ENSMUSP00000023709
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0097110 scaffold protein binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005882 intermediate filament
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0045095 keratin filament
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000186081
View Gene Order
ENSBTAG00000038384
Not yet available
Pathways
NETPATH
REACTOME
REACT_262098
Type I hemidesmosome assembly pathway
REACT_241978
Cell junction organization pathway
REACT_223082
Cell-Cell communication pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_20537
Type I hemidesmosome assembly pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
KEGG
INOH
PID NCI
reg_gr_pathway
Glucocorticoid receptor regulatory network
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt Q922U2
TrEMBL Q32P04 Q9CRS6
UniProt Splice Variant
Entrez Gene 110308
UniGene Mm.451847
RefSeq NM_027011
OMIM
CCDS CCDS27861
HPRD
IMGT
MGI ID MGI:96702
MGI Symbol Krt5
EMBL AF306785 AK014363 BC006780 BC108361 CH466550
GenPept AAH06780 AAI08362 AAL16774 BAB29298 EDL04029
RNA Seq Atlas 110308

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca