Homo sapiens Gene: GLRX5

Summary
InnateDB Gene IDBG-18709.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol GLRX5
Gene Name glutaredoxin 5
Synonyms C14orf87; FLB4739; GRX5; PR01238; PRO1238
Species Homo sapiens
Ensembl Gene ENSG00000182512
Encoded Proteins
IDBP-18711 glutaredoxin 5
IDBP-584588 glutaredoxin 5
Entrez Gene
Summary This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14: 95999840-96011061
Strand Forward strand
Band q32.13
Transcripts
ENST00000331334  ENSP00000328570
ENST00000553672 
ENST00000557731  ENSP00000451800
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein‑Protein  5
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0009055 electron carrier activity
GO:0015035 protein disulfide oxidoreductase activity
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0030097 hemopoiesis
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000021102 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000013423 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q86SX6 
TrEMBL
UniProt Splice Variant
Entrez Gene 51218 
UniGene Hs.728210
RefSeq NM_016417 
HUGO 20134 
OMIM 609588
CCDS CCDS9936 
HPRD 12659
IMGT
EMBL AB223038 BC023528 BC047680 BX248075 CH471061 DQ083331
GenPept AAH23528  AAH47680  AAZ30731  BAF02301  CAD62364  EAW81607 
ImmGen GLRX5 (murine) 
RNA Seq Atlas 51218