Homo sapiens Gene: GLRX5
Summary
InnateDB Gene IDBG-18709.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol GLRX5
Gene Name glutaredoxin 5
Synonyms C14orf87; FLB4739; GRX5; PR01238; PRO1238;
Species Homo sapiens
Ensembl Gene ENSG00000182512
Encoded Proteins
glutaredoxin 5
glutaredoxin 5
Protein Structure
Entrez Gene
Summary This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:95999840-96011061
Strand Forward strand
Band q32.13
Transcripts
ENST00000331334 ENSP00000328570
ENST00000553672
ENST00000557731 ENSP00000451800
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0009055 electron carrier activity
GO:0015035 protein disulfide oxidoreductase activity
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0030097 hemopoiesis
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q86SX6
TrEMBL
UniProt Splice Variant
Entrez Gene 51218
UniGene Hs.728210
RefSeq NM_016417
HUGO 20134
OMIM 609588
CCDS CCDS9936
HPRD 12659
IMGT
EMBL AB223038 BC023528 BC047680 BX248075 CH471061 DQ083331
GenPept AAH23528 AAH47680 AAZ30731 BAF02301 CAD62364 EAW81607
ImmGen GLRX5 (murine)
RNA Seq Atlas 51218