Version 5.4
Mus musculus Gene: Cdca8
Summary
InnateDB Gene IDBG-187104.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdca8
Gene Name cell division cycle associated 8
Synonyms 4831429J16Rik; AU044747; BOR; Borealin; D4Ertd421e; DasraB; MESRGP
Species Mus musculus
Ensembl Gene ENSMUSG00000028873
Encoded Proteins
IDBP-187106
cell division cycle associated 8
IDBP-187108
cell division cycle associated 8
IDBP-623514
cell division cycle associated 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134690:
This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:124918465-124939311
Strand Reverse strand
Band D2.2
Transcripts
ENSMUST00000084296 ENSMUSP00000081319
ENSMUST00000030690 ENSMUSP00000030690
ENSMUST00000135571
ENSMUST00000125801
ENSMUST00000147074
ENSMUST00000165281 ENSMUSP00000132145
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000089 mitotic metaphase
GO:0007067 mitotic nuclear division
GO:0051276 chromosome organization
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0010369 chromocenter
GO:0030496 midbody
GO:0032133 chromosome passenger complex
GO:0043234 protein complex
GO:0045171 intercellular bridge
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134690
View Gene Order
ENSBTAG00000014326
Not yet available
Pathways
NETPATH
REACTOME
REACT_249770
Cell Cycle, Mitotic pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_202512
Mitotic Anaphase pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_24
TSLP pathway
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID NCI
aurora_b_pathway
Aurora B signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28038
RefSeq NM_026560
OMIM
CCDS CCDS18631
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca