Version 5.4
| Mus musculus Gene: C1s | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-187200.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | C1s | ||||||||||
| Gene Name | complement component 1, s subcomponent | ||||||||||
| Synonyms | AA959438; AI255193; AI327365; C1s; C1sa | ||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Gene | ENSMUSG00000038521 | ||||||||||
| Encoded Proteins |
complement component 1, s subcomponent
complement component 1, s subcomponent
complement component 1, s subcomponent
complement component 1, s subcomponent
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| Protein Structure | |||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| InnateDB Annotation from Orthologs | |||||||||||
| Summary |
[Homo sapiens] C1S associates with C1R and C1Q to form the first component (C1) of the classical complement pathway.
[Homo sapiens] C1S is the modular serine protease responsible for cleavage of C4 and C2, the protein substrates for the first component (C1).
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| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182326:
This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 6:124530345-124542359 | ||||||||||
| Strand | Reverse strand | ||||||||||
| Band | F2 | ||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
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Gene ID
Gene Order
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| Pathways | |||||||||||
| NETPATH | |||||||||||
| REACTOME | |||||||||||
| KEGG |
Complement and coagulation cascades pathway
Systemic lupus erythematosus pathway
Staphylococcus aureus infection pathway
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| INOH | |||||||||||
| PID NCI | |||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Classical antibody-mediated complement activation pathway
Initial triggering of complement pathway
Innate Immune System pathway
Creation of C4 and C2 activators pathway
Immune System pathway
Complement cascade pathway
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| KEGG |
Complement and coagulation cascades pathway
Systemic lupus erythematosus pathway
Staphylococcus aureus infection pathway
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| INOH | |||||||||||
| PID NCI | |||||||||||
| Cross-References | |||||||||||
| SwissProt | |||||||||||
| TrEMBL | E0CYK5 E0CZE7 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 50908 | ||||||||||
| UniGene | Mm.219527 | ||||||||||
| RefSeq | NM_001097617 NM_144938 XM_006506365 | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS51907 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| MGI ID | MGI:1355312 | ||||||||||
| MGI Symbol | C1s1 | ||||||||||
| EMBL | AC161373 | ||||||||||
| GenPept | |||||||||||
| RNA Seq Atlas | 50908 | ||||||||||